Reverse muscle loss: Researchers identify nutrients that help protect our muscles.

A recent study by scientists has uncovered a promising strategy for combating age-related muscle degeneration, centered around the use of natural nutrients. The researchers found that a combination of nicotinamide (NAM) and pyridoxine (PN), both recognized as safe nutrients, is effective in supporting the function of muscle stem cells (MSCs), as reported by News Medical.

MSCs are crucial for muscle repair and regeneration, but their efficacy declines with age. Research published in The Journal of Clinical Investigation demonstrated that nicotinamide and pyridoxine work synergistically to enhance the activity of muscle-repairing cells. NAM amplifies signals within the cells that promote their proliferation, while PN supports the processes that enable these cells to develop and function optimally. Together, they make muscle recovery more efficient.

The study utilized advanced high-throughput screening of 50,000 nutrients and plant extracts derived from food sources. NAM and PN stood out due to their dual advantages of safety and efficacy. The findings were corroborated through in vitro experiments, in vivo tests on mouse models, and preclinical studies involving humans. Aging was linked to a natural decline in NAM and PN levels, which correlated with a reduction in muscle mass and a slowdown in walking speed among older adults. Supplementing with these nutrients effectively restored MSC functions, enhancing muscle regeneration and strength.

A key aspect of the study was its focus on physiological safety. Unlike earlier interventions that showed therapeutic potential but lacked confirmed safety for human use, NAM and PN represent a cost-effective and accessible approach to combat muscle loss while ensuring safety for the body. These conclusions are particularly significant for addressing the issue of sarcopenia—a condition characterized by a decrease in muscle mass and strength that severely impacts the quality of life for the aging population.

The combined therapy of NAM and PN not only reversed age-related changes in animal models but also showed promising results in humans, demonstrating improved muscle recovery and reduced healing time, the authors stated. However, their research notes that for optimal results, these supplements should complement physical activity and protein intake.

As the world increasingly faces the challenges of a globally aging population, this study presents a potentially viable, science-based intervention for enhancing the quality of life among older adults. The possibility of incorporating NAM and PN into clinical practice highlights the need for further investigation into their long-term effects and interactions with other treatments and preventive measures that promote health.

This material is for informational purposes only and does not contain advice that may affect your health. If you are experiencing health issues, please consult a specialist.